viernes, 23 de septiembre de 2016

TRIPTICO

Los grupos de ambos paralelos deben presentar el primer borrador de sus tripticos, hasta el 28 de septiembre.
Grupo que no presente el primero borrador del triptico hasta la fecha señalada será excluido de la feria, excepto los grupos que todavia estan defendiendo.A continuación esta un esquema global de distribucion del paper en el triptico.

GRUPOS PARA LA FERIA PARALELO IMPAR


1
APAZA OCHOA NESTOR
CO-OCCURRENCE OF RESISTANCE GENES TO ANTIBIOTICS, BIOCIDES AND METALS REVEALS NOVEL INSIGHTS INTO THEIR CO-SELECTION POTENTIAL
2
MENDOZA LOZA JUAN CARLOS
TARGETING REGULATORY T CELLS IN TUMORS
3
BALDERRAMA BUEZO MARIA GABRIELA
ROLE OF CHAPERONE MEDIATED AUTOPHAGY IN METABOLISM
4
RAMIREZ BALDERRAMA MIRIAM
DNA BARCODING: AN EFFICIENT TOOL TO OVERCOME AUTHETICATION CHALLENGES IN THE HERBAL MARKET
5
APAZA MAMANI JHONY VICTOR
THE ROLE OF PROTEIN “STABILITY PATCHES” IN MOLECULAR RECOGNITION: A CASE STUDY OF THE HUMAN GROWTH
6
VALLE GUTIERREZ MARIA ALEJANDRA
ERROR-PRONE REPAIR OF DNA DOUBLE-STRAND BREAKS
7
ALVARADO PATON LEYDY LAURA
CROSSOVER CONTROL STUDY OF THE EFFECT OF PERSONAL CARE PRODUCTS CONTAINING TRICLOSAN ON THE MICROBIOME
8
ALCON MARTINEZ LENNY ROSSANA
NUCLEAR SELENOPROTEINS AND GENOME MAINTENANCE
9
CACERES FLORES GUILLERMO MELVIN
COMBINATORIAL NANOMEDICINES FOR COLON CANCER THERAPY
10
CALLE MACHACA BANESA LEONOR
THE EMERGING ROLE OF NATIVE MASS SPECTROMETRY IN CHARACTERIZING THE STRUCTURE AND DYNAMICS OF MACROMOLECULAR COMPLEXES
11
AUZA PAREDES YOSELIN JUDITH
EMERGING ROLES OF LNCRNAs IN SENESCENCE
12
BERRIOS MARQUEZ JORGE IGNACIO
THE ROLE OF PROTEIN “STABILITY PATCHES” IN MOLECULAR RECOGNITION: A CASE STUDY OF THE HUMAN GROWTH HORMONE-RECEPTOR COMPLEX
13
BARRERA QUISPE MARIA TEREZA
IMPROVING COLD STORAGE AND PROCESSING TRAIS IN POTATO THROUGH TARGETED GENE KNOCKOUT
14
HUIZA MAYTA MARITZA ESTHER
QUANTITATIVE IMAGING WITH FUCCI AND MATHEMATICS TO UNCOVER TEMPORAL DYNAMIC OF CELL CYCLE PROGRESSION

miércoles, 21 de septiembre de 2016

TUTORIAL DE TRANSCRIPCION

Estimados estudiantes, mañana jueves se distribuira la tutorial de Transcripcion a las 15.30.  La lista del nuevo grupo esta en el blog del curso.

jueves, 15 de septiembre de 2016

ULTIMO GRUPO DE PAPERS (IMPAR)

Estimados estudiantes:
Este es el último grupo de papers, soliciten el lunes a partir de Hrs 12.00


BIOMOL(PAPERS)2016
GRUPO 8
LUNES
MARTES
MIERCOLES
JUEVES
VIERNES






1.     GENETIC OSCILLATORS IN DEVELOPMENT (PAPER4-8)
In development, morphogenetic processes are strictly coordinated in time. Cells in a developing tissue would need mechanisms for time-keeping. One such time-keeping mechanism is to use oscillations of gene expression. Oscillatory gene expression can be generated by transcriptional/translational feedback loops, usually referred to as a genetic oscillator. In this review article, we discuss genetic oscillators in the presence of developmental processes such as cell division, cell movement and cell differentiation. We first introduce the gene regulatory network for generating a rhythm of gene expression. We then discuss how developmental processes influence genetic oscillators. Examples include vertebrate somitogenesis and neural progenitor cell differentiation, as well as the circadian clock for comparison. To understand the behaviors of genetic oscillators in development, it is necessary to consider both gene expression dynamics and cellular behaviors simultaneously. Theoretical modeling combined with live imaging at single-cell resolution will be a powerful tool to analyze genetic oscillators in development.

PAPER 2
DAM IT’S GOOD! DAMID PROFILING OF PROTEIN-DNA INTERACTIONS  (paper 4-9)
The interaction of proteins with chromatin is fundamental for several essential cellular processes. During the development of an organism, genes must to be tightly regulated both temporally and spatially. This is achieved through the action of chromatin-binding proteins such as transcription factors, histone modifiers, nucleosome remodelers, and lamins. Furthermore, protein–DNA interactions are important in the adult, where their perturbation can lead to disruption of homeostasis, metabolic dysregulation, and diseases such as cancer. Understanding the nature of these interactions is of paramount importance in almost all areas of molecular biological research. In recent years, DNA adenine methyltransferase identification (DamID) has emerged as one of the most comprehensive and versatile methods available for profiling protein–DNA interactions on a genomic scale. DamID has been used to map a variety of chromatin-binding proteins in several model organisms and has the potential for continued adaptation and application in the field of genomic biology.
PAPER 3
In search for symmetries in the metabolism of cáncer (PAPER 4-10)
Even though aerobic glycolysis, or the Warburg effect, is arguably the most common
trait of metabolic reprogramming in cancer, it is unobserved in certain
tumor types. Systems biology advocates a global view on metabolism to dissect
which traits are consistently reprogrammed in cancer, and hence likely to constitute
an obligate step for the evolution of cancer cells. We refer to such traits as
symmetric. Here, we review early systems biology studies that attempted to
reveal symmetric traits in the metabolic reprogramming of cancer, discuss the
symmetry of reprogramming of nucleotide metabolism, and outline the current
limitations that, if unlocked, could elucidate whether symmetries in cancer
metabolism may be claimed.
PAPER 4
Methionine restriction and life-span control (PAPER 4-11)
Dietary restriction (DR) without malnutrition is associated with longevity in various organisms. However, it has also been shown that reduced calorie intake is often ineffective in extending life span. Selecting optimal dietary regimens for DR studies is complicated, as the same regimenmay lead to different outcomes depending on genotype
and environmental factors. Recent studies suggested that interventions such as moderate protein restriction with or without adequate nutrition (e.g., particular amino acids or carbohydrates) may have additional beneficial effects mediated by certain metabolic and hormonal factors implicated in the biology of aging, regardless of total calorie intake. In particular, it was shown that restriction of a single amino acid, methionine, can mimic the effects of DR and extend life span in variousmodel organisms.We discuss the beneficial effects of a methionine-restricted diet, the molecular pathways involved, and the use of this regimen in longevity interventions.
PAPER 5
Distinguishing between stochasticity and determinism: Examples from cell cycle duration variability (PAPER 4-13)
We describe a recent approach for distinguishing between stochastic and
deterministic sources of variability, focusing on the mammalian cell cycle.
Variability between cells is often attributed to stochastic noise, although it may
be generated by deterministic components. Interestingly, lineage information
can be used to distinguish between variability and determinism. Analysis of
correlations within a lineage of the mammalian cell cycle duration revealed its
deterministic nature. Here, we discuss the sources of such variability and the
possibility that the underlying deterministic process is due to the circadian
clock. Finally, we discuss the ‘‘kicked cell cycle’’ model and its implication on
the study of the cell cycle in healthy and cancerous tissues.
PAPER 6
Reprogramming the genetic code: The emerging role of ribosomal frameshifting in regulating cellular gene expression (PAPER 4-14)

Reading frame maintenance is a critical property of
ribosomes. However, a number of genetic elements have
been described that can induce ribosomes to shift on
mRNAs, the most well understood of which are a class that
directs ribosomal slippage by one base in 5’ (-1) direction.
This is referred to as programmed -1 ribosomal frameshifting
(-1 PRF). Recently, a new -1 PRF promoting
element was serendipitously discovered in a study
examining the effects of stretches of adenosines in the
coding sequences of mRNAs. Here, we discuss this
finding, recent studies describing how -1 PRF is used to
control gene expression in eukaryotes, and how -1 PRF is
itself regulated. The implications of dysregulation of -1 PRF
on human health are examined, as are possible new areas
in which novel -1 PRF promoting elements might be
discovered.
PAPER 7
Adenine methylation in eukaryotes: Apprehending the complex evolutionary
history and functional potential of an epigenetic modification (PAPER 4-15)

While N6-methyladenosine (m6A) is a well-known epigenetic
modification inbacterial DNA, it remainedlargely unstudied in
eukaryotes. Recent studies have brought to fore its potential
epigenetic role across diverse eukaryotes with biological
consequences,which aredistinctandpossibly evenopposite
to the well-studied 5-methylcytosine mark. Adenine methyltransferases
appear to have been independently acquired by
eukaryotes on at least 13 occasions from prokaryotic
restriction-modification and counter-restriction systems. On
at least four to five instances, thesemethyltransferases were
recruited as RNA methylases. Thus,m6Amarks in eukaryotic
DNAandRNAmightbemorewidespreadanddiversified than
previously believed. Several m6A-binding protein domains
from prokaryotes were also acquired by eukaryotes, facilitating
prediction of potential readers for these marks. Further,
multiple lineages of the AlkB family of dioxygenases have
been recruited as m6A demethylases. Although members of
the TET/JBP family of dioxygenases have also been
suggested to be m6A demethylases, this proposal needs
more careful evaluation.